Migraine Resources
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
A significant medication adaptation headache study was published two days ago. I was working on an article that now must change to include these new findings before publishing - hence the delay. This comprehensive MAH resource will be available today or tomorrow.
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
"CGRP-mAbs therapies combined with immunological treatments appear effective and safe in patients with autoimmune diseases."
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
This study found that migraine patients with frequent attacks (4+ monthly days) had impaired brain waste clearance function, which correlated with increased sensory sensitivity and may contribute to migraine progression.
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
How to Manage CGRP Injection Site Reactions
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
This study found that patients with right-to-left cardiac shunts (like PFO, measured by microbubble count) had significantly more severe migraine attacks, suggesting that the size of the PFO shunt, not just its presence, may help guide treatment decisions including possibility of surgical closure.
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
This study found that children w/ migraine had higher VIP levels during attacks & higher CGRP levels during pain-free periods compared to healthy controls. These could serve as potential blood biomarkers for diagnosing pediatric migraine as this population may be unable to describe their sxs clearly
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
This study found that migraine does not cause any detectable white matter structural damage to the brain, with no significant differences in white matter integrity between migraine patients and healthy controls across all migraine subtypes and phases.
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
Interesting case report of a patient who developed variant angina (coronary vasospasm) w/ chest pain and elevated troponins four days after starting Qulipta 60 mg daily for migraine prevention. Symptoms resolved after discontinuing the CGRP receptor antagonist and starting vasospasm treatment.
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
New Safety Insights from CGRP Antibody Study
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
This study found that chronic migraine patients with medication overuse/adaptation headache had excessive iron accumulation in brain reward regions that correlated with medication frequency, suggesting addiction-like neurobiological changes.
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
This study found that migraine patients with a patent foramen ovale have brain structure changes, including thicker outer brain layers and differences in protective nerve coating (myelin), suggesting myelin mapping could help identify and treat these patients.
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
Complete Guide to Triptans (Updated for 2025)
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
This study found that in a mouse model of chronic migraine, a type of tissue cell in the dura mater becomes highly inflammatory and recruits immune cells, creating a cycle of inflammation that leads to persistent chronic migraine pain and represents a potential new therapeutic target
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
"This study showed that SPG [sphenopalatine ganglion] blocks may be administered effectively in primary care settings or at home with proper patient education and are an effective treatment modality to decrease pain associated with acute migraine."
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
This study found that occipital nerve stimulation reduced pain intensity, headache frequency, and medication use in refractory chronic migraine patients at 12-month follow-up, but the presence of depression significantly reduced the likelihood of successful outcomes by 48%.
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
Dihydroergotamine (DHE) for Migraine Treatment (Updated for 2025)
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
This study found that ergotamine (migraine abortive) strengthens the body's internal 24-hour clock and is more effective when given during the day rather than at night. This suggests that timing headache treatments to match our natural daily rhythms could make them more effective.
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
Migraine Comorbidities (Updated for 2025)
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
This study found that people with migraine have elevated GFAP (glial activation marker) but normal NfL (nerve damage marker) levels, suggesting low-grade brain inflammation without nerve damage.
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
This case series found that patients experienced significant worsening of their migraine patterns after COVID-19 infection, including increased frequency, severity, duration, and reduced medication effectiveness.
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
Migraine Pathophysiology Explained (Updated for 2025)
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
This study found that peripheral nociceptors (pain-sensing nerve cells) are sexually dimorphic, with different mechanisms promoting migraine pain in men vs women. CGRP-targeting therapies may be more effective for acute treatment in women than men. More men are needed in migraine research.
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
This study found that taking triptan migraine medications during pregnancy, either alone or with other migraine drugs, does not significantly increase the risk of developmental disorders like autism, ADHD, or learning disabilities in children.
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
This study found that people with migraine experience significant cognitive impairments in working memory and cognitive inhibition during migraine attacks compared to the interictal phase (headache-free periods), highlighting an important aspect of migraine's functional burden.
The science behind migraine disease, or any type of headache, and migraine news. (Extension of Cerebral Torque's blog)
